Is it safe to take lamotrigine while pregnant?

The FDA-approved prescribing information says that lamotrigine “should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.” The “potential benefit” is generally the mother’s mental health condition.

Is lamotrigine safe to take during pregnancy?

Given its favorable reproductive safety profile, lamotrigine is a reasonable option for women who require treatment with a mood stabilizer during pregnancy.

Does Lamotrigine cause birth defects?

Although lamotrigine is commonly prescribed and has a good safety profile, a study in 2008 in the Neurology journal reported that lamotrigine exposure increased the frequency of congenital anomalies such as cleft palate in babies [Holmes L et al., 2008].

Can Lamictal cause a miscarriage?

There is currently no proof that lamotrigine use in pregnancy causes miscarriage or stillbirth.

What pregnancy category is lamotrigine?

Safety of Psychiatric Medications During Pregnancy and Lactation

Drug FDA pregnancy category*
Lamotrigine (Lamictal) C
Lithium D
Valproic acid (Depakene) D

Does Lamictal make it hard to get pregnant?

Studies have shown that men with seizure disorders as well as psychiatric disorders, such as bipolar disorder, may have lower fertility (make it harder for them to get their partner pregnant). Based on a small number of studies, lamotrigine does not seem to affect sperm counts, motility, or sex hormones in men.

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How safe is lamotrigine?

Lamotrigine (Lamictal) has been associated with a rare, but serious and life-threatening adverse reaction called hemophagocytic lymphohistiocytosis (HLH), which can lead to multi-organ failure resulting in hospitalization or death, particularly if diagnosis and treatment are delayed.

Does Lamictal cross the placenta?

Lamotrigine has a good tolerability and safety profile, but is known to cross the placenta. There is no consensus regarding its use in pregnancy.

Does Lamotrigine cause weight gain?

Low risk of weight gain: Lamotrigine (Lamictal) is most likely to cause weight loss. However, it can also cause weight gain. Other common side effects of this drug include: headache.

Can you take folic acid with lamotrigine?

A secondary analysis suggested that folic acid administration might dampen lamotrigine’s antidepressant effect. The researchers concluded that the combination of lamotrigine and folate should be avoided, and cautioned about the potential effect of widespread folic acid fortification on lamotrigine’s efficacy.

What are the safest antidepressants during pregnancy?

Antidepressants that are considered safer include:

  • Fluoxetine (Prozac, Sarafem)
  • Citalopram (Celexa)
  • Sertraline (Zoloft)
  • Amitriptyline (Elavil)
  • Desipramine (Norpramin)
  • Nortriptyline (Pamelor)
  • Bupropion (Wellbutrin)

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Can pregnancy make bipolar worse?

And the factors that lead to relapse during pregnancy are not clear. Bipolar disorder, however, can worsen during pregnancy. Pregnant women or new mothers with bipolar disorder have seven times the risk of hospital admissions compared to pregnant women who do not have bipolar disorder.

Is Lamictal safe long term?

Many people can take lamotrigine safely for several months or years. But there are some side effects that might happen over a long time. Long-term treatment with lamotrigine can cause osteoporosis and osteopenia, increasing your risk of breaking a bone.

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Does Lamictal deplete folic acid?

Anticonvulsants that do not induce cytochrome P450 enzymes, such as lamotrigine (Lamictal), are not associated with low levels of folic acid.

Can Lamictal cause autism?

Findings from a recent study published in Neurology reveal that the use of lamotrigine in patients with epilepsy who are pregnant does not increase the incidence of autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) in children; however, valproic acid was associated with a higher risk of …

Is Category C safe during pregnancy?

Category C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.